Specifications/Features
Specificity: Raised against a peptide representing an invariant cytoplasmic sequence within the CD3epsilon chain recognizes human CD3epsilon. CD3 is a multimeric protein complex composed of four distinct polypeptide chains (epsilon, gamma, delta, zeta) that assemble and function as three pairs of dimers (epsilon-gamma, epsilon-delta, zeta-zeta;). The CD3 complex serves as a T cell co-receptor that associates non-covalently with the T cell receptor (TCR) ; ;. CD3 is a defining feature of cells belonging to the T cell lineage and can therefore be used as T cell marker. Ashas been specifically raised against an epitope within the epsilon peptide chain, highly conserved among species clone CD3-12 has a very broad species cross-reactivity for the CD3 marker. ;